Imaging most of a worm’s brain activity at high resolution and in a single operation | KurzweilAI

Imaging most of a worm’s brain activity at high resolution and in a single operation | KurzweilAI: Visualizing the neurons also requires tagging them with a fluorescent protein that lights up when it binds to calcium, signaling the nerve cells’ activity.

“The neurons in a worm’s head are so densely packed that we could not distinguish them on our first images...”

“Our solution was to insert the calcium sensor into the nuclei rather than the entire cells, thereby sharpening the image so we could identify single neurons.”