Tracking neuronal activity in the living brain

Tracking neuronal activity in the living brain: "YC-Nano accurately tracked the complex patterns of Ca2+ activation seen in the aggregating process of social amoeba Dictyostelium, revealing propagating waves throughout the aggregates in a rotating spiral. These indicators also performed well in monitoring neuronal activity in the brains of mice, and Mikoshiba foresees numerous experimental applications in the near future. “Since YC-Nano can be stably expressed in specific types of neurons for a long range of time,” he says, “we expect to perform chronic in vivo imaging and analyze the modifications of neuronal network activities underlying learning, development or diseases of the brain.”